Physiological and molecular study on the anti-obesity effects of pineapple juice in male Wistar rat, Food science and Biotechnology, US National Library of Medicine, National Institutes of Health. Honey promotes lower weight gain, adiposity, and triglycerides than sucrose in rats, Nutrition Research, US National Library of Medicine, National Institutes of Dr Juan Rivera Keto has strict sourcing guidelines and relies on peer-reviewed studies, academic research institutions, and medical associations. You can learn more about how we ensure our content is accurate and current by reading our editorial policy. Phase one detoxification consists of oxidation reduction and hydrolysis. Phase one detoxification is catalysed by enzymes referred to as the cytochrome P450 enzyme group or Mixed Function Oxidase enzymes MFO. These enzymes reside on the membrane system of the liver cells . Human liver cells possess the genetic code for many isoenzymes of P-450 whose synthesis can be induced upon exposure to specific chemicals.